As in the original Minecraft digital game, in Minecraft: Builders & Biomes players explore the Overworld, build structures, and mine resources, earning points for structures and the largest connected biomes of forest, desert, mountain, or snowy tundra spaces on their player boards.

Familiar foes like Endermen, Creepers, and other mobs also appear throughout the game, and they need to be defeated using weapons collected from the board. Defeating mobs earn players points in addition to granting additional awards. Game scoring occurs as the resource cube's layers are depleted. As soon as the third layer runs out, the adventure comes to an end, and the builder with the most points wins.